226.GLOBAL EPILEPSY TREATMENT DATA ANALYSIS USING PROC OPTIONS | PROC FORMAT | PROC PRINT | PROC CONTENTS | PROC FREQ | PROC MEANS | PROC SGPLOT | PROC SQL | PROC EXPORT | PROC COMPARE

GLOBAL EPILEPSY TREATMENT DATA ANALYSIS USING PROC OPTIONS | PROC FORMAT | PROC PRINT | PROC CONTENTS | PROC FREQ | PROC MEANS | PROC SGPLOT | PROC SQL | PROC EXPORT | PROC COMPARE

 /*Worldwide epilepsy‑treatment dataset*/

1.Global program‑level OPTIONS (good style)

options nocenter nodate nonumber ls=132 ps=60

        varlenchk=NOWARN         /* ignore length “shrinking” */

        fmtsearch=(work);        /* look‑up custom formats    */

2.Creating the 25‑row dataset

data work.epil_world;

   length PatientID $8  Country $20 Region $15  EpilepsyType $25

          Sex $1 PrimaryDrug $15 SeizureControl $12 TreatmentRegimen $10 ;

   format DiagnosisDate TreatmentStart TreatmentEnd date9. ;

   infile datalines dsd truncover;

   input PatientID Country Region EpilepsyType $

         Age Sex $

         DiagnosisDate :date9.

         TreatmentStart :date9.

         TreatmentEnd   :date9.

         PrimaryDrug $ SeizureControl $ ;

   /*—— DERIVE LENGTH‑OF‑TREATMENT ——*/

   DurationMonths = intck('month', TreatmentStart, TreatmentEnd );

   /*—— DERIVE REGIMEN TYPE ——*/

   TreatmentRegimen = ifc(DurationMonths>24, 'Poly', 'Mono');

   label DurationMonths = 'Treatment Duration (Months)';

datalines;

P001,India,Asia,Focal,24,M,05JAN2022,15JAN2022,15JUL2024,Levetiracetam,Controlled

P002,USA,NorthAmerica,Generalized,32,F,20MAR2021,10APR2021,10JUN2023,Valproate,Partial

P003,Brazil,SouthAmerica,Focal_to_Bilateral,45,M,12DEC2019,01JAN2020,01JAN2024,Carbamazepine,Controlled

P004,UK,Europe,Generalized,29,F,15FEB2020,20FEB2020,20FEB2022,Topiramate,Controlled

P005,Japan,Asia,Focal,38,M,01AUG2018,15AUG2018,15FEB2025,Lacosamide,Uncontrolled

P006,Nigeria,Africa,Unknown,27,F,10OCT2022,20OCT2022,20APR2024,Phenytoin,Partial

P007,Germany,Europe,Focal,51,M,05MAY2017,20MAY2017,20MAY2020,Carbamazepine,Controlled

P008,Canada,NorthAmerica,Generalized,33,F,02JAN2023,05JAN2023,05JUL2024,Valproate,Partial

P009,Australia,Oceania,Focal,41,M,22JUL2020,01AUG2020,01FEB2023,Levetiracetam,Controlled

P010,India,Asia,Focal_to_Bilateral,16,F,12SEP2023,15SEP2023,15MAR2025,Oxcarbazepine,Uncontrolled

P011,France,Europe,Generalized,60,M,20APR2016,01MAY2016,01MAY2024,Valproate,Controlled

P012,Brazil,SouthAmerica,Focal,34,F,15NOV2020,20NOV2020,20NOV2023,Lacosamide,Partial

P013,USA,NorthAmerica,Unknown,22,M,01JAN2024,15JAN2024,15JUN2024,Levetiracetam,Uncontrolled

P014,Japan,Asia,Generalized,57,F,10JUN2019,20JUN2019,20DEC2023,Topiramate,Controlled

P015,India,Asia,Focal,30,M,05JUL2021,10JUL2021,10JAN2025,Carbamazepine,Partial

P016,Kenya,Africa,Focal,28,F,22FEB2022,01MAR2022,01MAR2024,Lacosamide,Controlled

P017,UK,Europe,Unknown,46,M,11NOV2020,20NOV2020,20NOV2023,Phenytoin,Partial

P018,USA,NorthAmerica,Focal_to_Bilateral,37,F,01APR2022,10APR2022,10OCT2024,Valproate,Controlled

P019,Australia,Oceania,Generalized,19,M,01JAN2023,05JAN2023,05JAN2025,Levetiracetam,Controlled

P020,India,Asia,Focal,52,F,15DEC2018,01JAN2019,01JAN2024,Carbamazepine,Uncontrolled

P021,Germany,Europe,Focal,48,M,20MAY2020,25MAY2020,25NOV2023,Lacosamide,Partial

P022,Canada,NorthAmerica,Generalized,31,F,02FEB2021,10FEB2021,10AUG2023,Topiramate,Controlled

P023,Nigeria,Africa,Focal_to_Bilateral,43,M,08AUG2019,15AUG2019,15FEB2023,Valproate,Partial

P024,Brazil,SouthAmerica,Generalized,26,F,10DEC2022,20DEC2022,20JUN2024,Phenytoin,Controlled

P025,Japan,Asia,Unknown,55,M,01SEP2020,10SEP2020,10MAR2023,Levetiracetam,Uncontrolled

;

run;

proc print;run;

Output:

Obs	PatientID	Country	Region	EpilepsyType	Sex	PrimaryDrug	SeizureControl	TreatmentRegimen	DiagnosisDate	TreatmentStart	TreatmentEnd	Age	DurationMonths
1	P001	India	Asia	Focal	M	Levetiracetam	Controlled	Poly	05JAN2022	15JAN2022	15JUL2024	24	30
2	P002	USA	NorthAmerica	Generalized	F	Valproate	Partial	Poly	20MAR2021	10APR2021	10JUN2023	32	26
3	P003	Brazil	SouthAmerica	Focal_to_Bilateral	M	Carbamazepine	Controlled	Poly	12DEC2019	01JAN2020	01JAN2024	45	48
4	P004	UK	Europe	Generalized	F	Topiramate	Controlled	Mono	15FEB2020	20FEB2020	20FEB2022	29	24
5	P005	Japan	Asia	Focal	M	Lacosamide	Uncontrolled	Poly	01AUG2018	15AUG2018	15FEB2025	38	78
6	P006	Nigeria	Africa	Unknown	F	Phenytoin	Partial	Mono	10OCT2022	20OCT2022	20APR2024	27	18
7	P007	Germany	Europe	Focal	M	Carbamazepine	Controlled	Poly	05MAY2017	20MAY2017	20MAY2020	51	36
8	P008	Canada	NorthAmerica	Generalized	F	Valproate	Partial	Mono	02JAN2023	05JAN2023	05JUL2024	33	18
9	P009	Australia	Oceania	Focal	M	Levetiracetam	Controlled	Poly	22JUL2020	01AUG2020	01FEB2023	41	30
10	P010	India	Asia	Focal_to_Bilateral	F	Oxcarbazepine	Uncontrolled	Mono	12SEP2023	15SEP2023	15MAR2025	16	18
11	P011	France	Europe	Generalized	M	Valproate	Controlled	Poly	20APR2016	01MAY2016	01MAY2024	60	96
12	P012	Brazil	SouthAmerica	Focal	F	Lacosamide	Partial	Poly	15NOV2020	20NOV2020	20NOV2023	34	36
13	P013	USA	NorthAmerica	Unknown	M	Levetiracetam	Uncontrolled	Mono	01JAN2024	15JAN2024	15JUN2024	22	5
14	P014	Japan	Asia	Generalized	F	Topiramate	Controlled	Poly	10JUN2019	20JUN2019	20DEC2023	57	54
15	P015	India	Asia	Focal	M	Carbamazepine	Partial	Poly	05JUL2021	10JUL2021	10JAN2025	30	42
16	P016	Kenya	Africa	Focal	F	Lacosamide	Controlled	Mono	22FEB2022	01MAR2022	01MAR2024	28	24
17	P017	UK	Europe	Unknown	M	Phenytoin	Partial	Poly	11NOV2020	20NOV2020	20NOV2023	46	36
18	P018	USA	NorthAmerica	Focal_to_Bilateral	F	Valproate	Controlled	Poly	01APR2022	10APR2022	10OCT2024	37	30
19	P019	Australia	Oceania	Generalized	M	Levetiracetam	Controlled	Mono	01JAN2023	05JAN2023	05JAN2025	19	24
20	P020	India	Asia	Focal	F	Carbamazepine	Uncontrolled	Poly	15DEC2018	01JAN2019	01JAN2024	52	60
21	P021	Germany	Europe	Focal	M	Lacosamide	Partial	Poly	20MAY2020	25MAY2020	25NOV2023	48	42
22	P022	Canada	NorthAmerica	Generalized	F	Topiramate	Controlled	Poly	02FEB2021	10FEB2021	10AUG2023	31	30
23	P023	Nigeria	Africa	Focal_to_Bilateral	M	Valproate	Partial	Poly	08AUG2019	15AUG2019	15FEB2023	43	42
24	P024	Brazil	SouthAmerica	Generalized	F	Phenytoin	Controlled	Mono	10DEC2022	20DEC2022	20JUN2024	26	18
25	P025	Japan	Asia	Unknown	M	Levetiracetam	Uncontrolled	Poly	01SEP2020	10SEP2020	10MAR2023	55	30

3.First‑look exploration

3.1 What’s inside? (PROC CONTENTS)

proc contents data=work.epil_world varnum;

   title "Structure of EPIL_W (Worldwide Epilepsy Study)";

run;

Output:

Structure of EPIL_WORLD (Worldwide Epilepsy Study)

The CONTENTS Procedure

Data Set Name	WORK.EPIL_WORLD	Observations	25
Member Type	DATA	Variables	13
Engine	V9	Indexes	0
Created	14/09/2015 00:06:14	Observation Length	152
Last Modified	14/09/2015 00:06:14	Deleted Observations	0
Protection		Compressed	NO
Data Set Type		Sorted	NO
Label
Data Representation	WINDOWS_64
Encoding	wlatin1 Western (Windows)

Engine/Host Dependent Information
Data Set Page Size	65536
Number of Data Set Pages	1
First Data Page	1
Max Obs per Page	430
Obs in First Data Page	25
Number of Data Set Repairs	0
ExtendObsCounter	YES
Filename	C:\Users\Lenovo\AppData\Local\Temp\SAS Temporary Files\_TD10416_DESKTOP-QFAA4KV_\epil_world.sas7bdat
Release Created	9.0401M2
Host Created	X64_8HOME

Variables in Creation Order
#	Variable	Type	Len	Format	Label
1	PatientID	Char	8
2	Country	Char	20
3	Region	Char	15
4	EpilepsyType	Char	25
5	Sex	Char	1
6	PrimaryDrug	Char	15
7	SeizureControl	Char	12
8	TreatmentRegimen	Char	10
9	DiagnosisDate	Num	8	DATE9.
10	TreatmentStart	Num	8	DATE9.
11	TreatmentEnd	Num	8	DATE9.
12	Age	Num	8
13	DurationMonths	Num	8		Treatment Duration (Months)

3.2 Raw peek (PROC PRINT with WHERE)

proc print data=work.epil_world(obs=10);

   title "First 10 Records – Sanity Check";

   where Country in ('India','USA');

run;

Output:

First 10 Records – Sanity Check

Obs	PatientID	Country	Region	EpilepsyType	Sex	PrimaryDrug	SeizureControl	TreatmentRegimen	DiagnosisDate	TreatmentStart	TreatmentEnd	Age	DurationMonths
1	P001	India	Asia	Focal	M	Levetiracetam	Controlled	Poly	05JAN2022	15JAN2022	15JUL2024	24	30
2	P002	USA	NorthAmerica	Generalized	F	Valproate	Partial	Poly	20MAR2021	10APR2021	10JUN2023	32	26
10	P010	India	Asia	Focal_to_Bilateral	F	Oxcarbazepine	Uncontrolled	Mono	12SEP2023	15SEP2023	15MAR2025	16	18
13	P013	USA	NorthAmerica	Unknown	M	Levetiracetam	Uncontrolled	Mono	01JAN2024	15JAN2024	15JUN2024	22	5
15	P015	India	Asia	Focal	M	Carbamazepine	Partial	Poly	05JUL2021	10JUL2021	10JAN2025	30	42
18	P018	USA	NorthAmerica	Focal_to_Bilateral	F	Valproate	Controlled	Poly	01APR2022	10APR2022	10OCT2024	37	30
20	P020	India	Asia	Focal	F	Carbamazepine	Uncontrolled	Poly	15DEC2018	01JAN2019	01JAN2024	52	60

4.Descriptive statistics

4.1 Demographics by epilepsy type (PROC FREQ)

proc freq data=work.epil_world order=freq;

   table EpilepsyType*Sex / nocol nopercent nocum;

   title "Sex Distribution by Epilepsy Classification";

run;

Output:

Sex Distribution by Epilepsy Classification

The FREQ Procedure

Frequency Row Pct

Table of EpilepsyType by Sex EpilepsyType Sex M F Total Focal 6 66.67 3 33.33 9   Generalized 2 25.00 6 75.00 8   Focal_to_Bilateral 2 50.00 2 50.00 4   Unknown 3 75.00 1 25.00 4   Total 13 12 25

4.2 Treatment length distribution (PROC MEANS)

proc means data=work.epil_world n mean median min max maxdec=1;

   class EpilepsyType;

   var DurationMonths Age;

   title "Duration & Age, Broken Down by Epilepsy Class";

run;

Output:

Duration & Age, Broken Down by Epilepsy Class

The MEANS Procedure

EpilepsyType	N Obs	Variable	Label	N	Mean	Median	Minimum	Maximum
Focal	9	DurationMonths Age	Treatment Duration (Months)	9 9	42.0 38.4	36.0 38.0	24.0 24.0	78.0 52.0
Focal_to_Bilateral	4	DurationMonths Age	Treatment Duration (Months)	4 4	34.5 35.3	36.0 40.0	18.0 16.0	48.0 45.0
Generalized	8	DurationMonths Age	Treatment Duration (Months)	8 8	36.3 35.9	25.0 31.5	18.0 19.0	96.0 60.0
Unknown	4	DurationMonths Age	Treatment Duration (Months)	4 4	22.3 37.5	24.0 36.5	5.0 22.0	36.0 55.0

4.3 Quick plot (PROC SGPLOT with summary function)

proc sgplot data=work.epil_world;

   vbox DurationMonths / category=Region;

   title "Boxplot: Months on Treatment by Global Region";

run;

Log:

NOTE: PROCEDURE SGPLOT used (Total process time):

      real time           3.32 seconds

      cpu time            0.56 seconds

NOTE: Listing image output written to SGPlot1.png.

NOTE: There were 25 observations read from the data set WORK.EPIL_WORLD.

5.Custom formats to declutter outputs

proc format;

   value $reg 'NorthAmerica' = 'N. America'

              'SouthAmerica' = 'S. America'

              'Oceania'      = 'Oce'

              other          = 'OTHER';

run;

proc freq data=work.epil_world;

   format Region $reg.;

   tables Region*SeizureControl / norow nocol nopercent;

   title "Outcome vs Region Using User Format";

run;

Output:

Outcome vs Region Using User Format

The FREQ Procedure

Frequency

Table of Region by SeizureControl Region SeizureControl Controlled Partial Uncontrolled Total OTHER 6 5 4 15 N. America 2 2 1 5 Oce 2 0 0 2 S. America 2 1 0 3 Total 12 8 5 25

6.Analytic SQL snippets

proc sql;

   title "Mean Treatment Duration by Country & Control Status";

   select Country,

          SeizureControl,

          count(*)               as N_Patients,

          mean(DurationMonths)   as Avg_Months format=5.1

   from   work.epil_world

   group  by Country, SeizureControl

   having calculated Avg_Months > 18

   order  by Avg_Months desc;

quit;

Output:

Mean Treatment Duration by Country & Control Status

Country	SeizureControl	N_Patients	Avg_Months
France	Controlled	1	96.0
Japan	Uncontrolled	2	54.0
Japan	Controlled	1	54.0
Germany	Partial	1	42.0
India	Partial	1	42.0
India	Uncontrolled	2	39.0
UK	Partial	1	36.0
Germany	Controlled	1	36.0
Brazil	Partial	1	36.0
Brazil	Controlled	2	33.0
Nigeria	Partial	2	30.0
Canada	Controlled	1	30.0
India	Controlled	1	30.0
USA	Controlled	1	30.0
Australia	Controlled	2	27.0
USA	Partial	1	26.0
UK	Controlled	1	24.0
Kenya	Controlled	1	24.0

7.Reusable macro: %SummaryBy

%macro SummaryBy(data=, class=, statvar=, outfile=);

   %local i n var;

   %let n=%sysfunc(countw(&class));

   %do i=1 %to &n;

      %let var=%scan(&class,&i);

      title "===&var Summary===";

      proc means data=&data n mean median maxdec=1;

         class &var;

         var &statvar;

      run;

      proc freq data=&data;

         tables &var / nocum nopercent;

      run;

      /*—— optional export ——*/

      %if %length(&outfile) %then %do;

         proc export data=&data(keep=&var &statvar)

             outfile="&outfile._&var..csv"

             dbms=csv replace;

         run;

      %end;

   %end;

%mend SummaryBy;

%SummaryBy(data=work.epil_world,

           class=Region EpilepsyType TreatmentRegimen,

           statvar=DurationMonths,

           outfile=%sysfunc(pathname(work))/epil_out);

Output:

===Region Summary===

The MEANS Procedure

Analysis Variable : DurationMonths Treatment Duration (Months)
Region	N Obs	N	Mean	Median
Africa	3	3	28.0	24.0
Asia	7	7	44.6	42.0
Europe	5	5	46.8	36.0
NorthAmerica	5	5	21.8	26.0
Oceania	2	2	27.0	27.0
SouthAmerica	3	3	34.0	36.0

===Region Summary===

The FREQ Procedure

Region	Frequency
Africa	3
Asia	7
Europe	5
NorthAmerica	5
Oceania	2
SouthAmerica	3

===EpilepsyType Summary===

The MEANS Procedure

Analysis Variable : DurationMonths Treatment Duration (Months)
EpilepsyType	N Obs	N	Mean	Median
Focal	9	9	42.0	36.0
Focal_to_Bilateral	4	4	34.5	36.0
Generalized	8	8	36.3	25.0
Unknown	4	4	22.3	24.0

===EpilepsyType Summary===

The FREQ Procedure

EpilepsyType	Frequency
Focal	9
Focal_to_Bilateral	4
Generalized	8
Unknown	4

===TreatmentRegimen Summary===

The MEANS Procedure

Analysis Variable : DurationMonths Treatment Duration (Months)
TreatmentRegimen	N Obs	N	Mean	Median
Mono	8	8	18.6	18.0
Poly	17	17	43.9	36.0

===TreatmentRegimen Summary===

The FREQ Procedure

TreatmentRegimen	Frequency
Mono	8
Poly	17

8.Quality‑control snapshot

Compare derived vs re‑computed (PROC COMPARE)

data qc;

   set work.epil_world;

   RecalcMonths = intck('month', TreatmentStart, TreatmentEnd);

run;

proc print;run;

Obs	PatientID	Country	Region	EpilepsyType	Sex	PrimaryDrug	SeizureControl	TreatmentRegimen	DiagnosisDate	TreatmentStart	TreatmentEnd	Age	DurationMonths	RecalcMonths
1	P001	India	Asia	Focal	M	Levetiracetam	Controlled	Poly	05JAN2022	15JAN2022	15JUL2024	24	30	30
2	P002	USA	NorthAmerica	Generalized	F	Valproate	Partial	Poly	20MAR2021	10APR2021	10JUN2023	32	26	26
3	P003	Brazil	SouthAmerica	Focal_to_Bilateral	M	Carbamazepine	Controlled	Poly	12DEC2019	01JAN2020	01JAN2024	45	48	48
4	P004	UK	Europe	Generalized	F	Topiramate	Controlled	Mono	15FEB2020	20FEB2020	20FEB2022	29	24	24
5	P005	Japan	Asia	Focal	M	Lacosamide	Uncontrolled	Poly	01AUG2018	15AUG2018	15FEB2025	38	78	78
6	P006	Nigeria	Africa	Unknown	F	Phenytoin	Partial	Mono	10OCT2022	20OCT2022	20APR2024	27	18	18
7	P007	Germany	Europe	Focal	M	Carbamazepine	Controlled	Poly	05MAY2017	20MAY2017	20MAY2020	51	36	36
8	P008	Canada	NorthAmerica	Generalized	F	Valproate	Partial	Mono	02JAN2023	05JAN2023	05JUL2024	33	18	18
9	P009	Australia	Oceania	Focal	M	Levetiracetam	Controlled	Poly	22JUL2020	01AUG2020	01FEB2023	41	30	30
10	P010	India	Asia	Focal_to_Bilateral	F	Oxcarbazepine	Uncontrolled	Mono	12SEP2023	15SEP2023	15MAR2025	16	18	18
11	P011	France	Europe	Generalized	M	Valproate	Controlled	Poly	20APR2016	01MAY2016	01MAY2024	60	96	96
12	P012	Brazil	SouthAmerica	Focal	F	Lacosamide	Partial	Poly	15NOV2020	20NOV2020	20NOV2023	34	36	36
13	P013	USA	NorthAmerica	Unknown	M	Levetiracetam	Uncontrolled	Mono	01JAN2024	15JAN2024	15JUN2024	22	5	5
14	P014	Japan	Asia	Generalized	F	Topiramate	Controlled	Poly	10JUN2019	20JUN2019	20DEC2023	57	54	54
15	P015	India	Asia	Focal	M	Carbamazepine	Partial	Poly	05JUL2021	10JUL2021	10JAN2025	30	42	42
16	P016	Kenya	Africa	Focal	F	Lacosamide	Controlled	Mono	22FEB2022	01MAR2022	01MAR2024	28	24	24
17	P017	UK	Europe	Unknown	M	Phenytoin	Partial	Poly	11NOV2020	20NOV2020	20NOV2023	46	36	36
18	P018	USA	NorthAmerica	Focal_to_Bilateral	F	Valproate	Controlled	Poly	01APR2022	10APR2022	10OCT2024	37	30	30
19	P019	Australia	Oceania	Generalized	M	Levetiracetam	Controlled	Mono	01JAN2023	05JAN2023	05JAN2025	19	24	24
20	P020	India	Asia	Focal	F	Carbamazepine	Uncontrolled	Poly	15DEC2018	01JAN2019	01JAN2024	52	60	60
21	P021	Germany	Europe	Focal	M	Lacosamide	Partial	Poly	20MAY2020	25MAY2020	25NOV2023	48	42	42
22	P022	Canada	NorthAmerica	Generalized	F	Topiramate	Controlled	Poly	02FEB2021	10FEB2021	10AUG2023	31	30	30
23	P023	Nigeria	Africa	Focal_to_Bilateral	M	Valproate	Partial	Poly	08AUG2019	15AUG2019	15FEB2023	43	42	42
24	P024	Brazil	SouthAmerica	Generalized	F	Phenytoin	Controlled	Mono	10DEC2022	20DEC2022	20JUN2024	26	18	18
25	P025	Japan	Asia	Unknown	M	Levetiracetam	Uncontrolled	Poly	01SEP2020	10SEP2020	10MAR2023	55	30	30

proc compare base=qc(rename=(DurationMonths=Dur1))

             compare=qc(rename=(RecalcMonths=Dur2))

             criterion=0.0001 /* tolerance */

             out=diff(where=(difference ne 0));

   id PatientID;

   var Dur1;

   with Dur2;

   title "QC: Derived Duration vs Recalc";

run;

Output:

QC: Derived Duration vs Recalc

The COMPARE Procedure Comparison of WORK.QC with WORK.QC (Method=RELATIVE(2.22E-10), Criterion=0.0001) Data Set Summary Dataset Created Modified NVar NObs WORK.QC 14SEP15:00:35:14 14SEP15:00:35:14 14 25 WORK.QC 14SEP15:00:35:14 14SEP15:00:35:14 14 25 Variables Summary Number of Variables in Common: 12. Number of Variables in WORK.QC but not in WORK.QC: 2. Number of Variables in WORK.QC but not in WORK.QC: 2. Number of ID Variables: 1. Number of VAR Statement Variables: 1. Number of WITH Statement Variables: 1.

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